I found these on imdb:

--In certain episodes, the floor in the upstairs hallway changes from hardwood, to carpet, then back again.

--In the living room, the rug will be purple, and either in the next couple scenes or in the next episode it will be yellow and vice-versa.

--Brian's voice is simply Seth MacFarlane speaking normally.

--Stewie's voice is based on Rex Harrison.

--Seth Green reveals in the commentary for Family Guy Presents Stewie Griffin: The Untold Story (2005) (V) that the voice of Chris is based on Ted Levine's performance as Buffalo Bill in The Silence of the Lambs (1991).

--This series is banned in Indonesia, Taiwan, Vietnam, Iran, South Korea, South Africa, and Malaysia.

--Every episode includes at least one instance of one character saying "What the hell..." to another.

--The most frequent animation error seen in the show is the appearance of the eyebrows (and some cases the eyes). The eyebrows are known to disappear and/or reappear at times, or in rare cases even "duplicate", creating an extra pair of eyebrows (as seen on Lois' father when Peter meets him in "Death Lives").

--When Lois is in jail following her stealing spree, she's wearing her standard yellow prison garb. When Peter sticks her in his mouth to smuggle her out, she's back to her normal clothes.

--In "No Chris Left Behind", the Morningwood Academy sign has "NO IRISH" crossed out and "IRISH OK" written under it. The next time we see the sign, there is no trace whatsoever of either line of the Irish text.