It sounds like you have your sights set on this company and this is a big deal to you. Can you call and ask who the Manager of HR is and how they prefer to receive resumes? That way you know who you are addressing and the best way to submit your information. If it is a fairly large company you should be able to speak with a receptionist and get transferred to the HR department or, at least, get contact information and a name from them.

In this job market I would make the most effort if you want the job. It can't hurt to try but, honestly, if it didn't sound as though this company is the ONE company you want to work for I would not give you this advice. Because if you are sending out your resume to 100 plus businesses then doing this for every one would be exhausting image.