Definitely wouldn't waste your time in the flats...

But as someone above me said, DEFINITELY go to East 4th Street, right near House of Blues. There's an awesome Mexican restaurant there, I forget the name, but it wouldn't be hard to find. There's also a cool place around the corner on Euclid called Cadillac Ranch that's newer and really good/fun. I love E. 4th, they've really made it pretty awesome over time. It used to be just an alley with nothing and it's developed into all these awesome little restaurants and bars, and a comedy club, with outside seating and cute little lights and stuff.

Also, I don't know if you're driving or whatever, but if you are and you need somewhere to park, East 4th street valet is only $8 bucks and it's right near everything. Most of the parking garages and especially event parking near The Q and RR Hall of Fame are probably more than $8. Plus, it's really convenient.