That makes me sad that this girl's mother is "parenting" her child by shipping her off to her uncle's house across the country. I know this has nothing to do with you or the situation you are asking advice about. It sounds like you are concerned, I'm just not sure if it's your place to say anything about it directly to her. I like that you are trying to help out positively when you can. Maybe asking her if she wants to do something out of the house, just you two? Like going to the movies, or to a frozen yogurt shop. That may help her feel more comfortable since she can get out of the house, and maybe you can be a good role model for her.